| Vol. 23, No. 10 |
|
| Top | Previous | Next |
In his classic work entitled
The White Company, Sir Arthur Conan Doyle spins a tale about a company of 300 English longbow men and the knights who led them or opposed them in war against France and Spain. In addition to a wonderful vicarious adventure, Doyle also provides the readers of this book with a vivid lesson in the culture and living conditions of medieval England and France at the time when the long bow, cross bow, sword, spear, and lance were just beginning to feel the competition of gunpowder.Included are a wide variety of characters - thieving and generous, lying and truthful, drunk and sober - cutthroats, fair damsels, monks, merchants, brave soldiers, cowards, and many others - possessing the usual cross section of virtues and foibles with which the human race has been blessed and cursed for thousands of years.
Standing at the apex of this society were the knights and their retainers, who possessed an extremely rigid and lofty code of personal honor. Although coarse brutality with hand weapons was a way of life for these men, they simultaneously held to a very high standard of truth, justice, and ethical behavior. This standard provided the glue that held their civilization together. Passed down through the centuries to us, their standard today provides essential principles that help prevent our modern civilization from descending into the base forms of anarchy whereto the darker aspects of the human spirit would lead.
Sir Doyle ends
The White Company with these words:"So they lived, these men, in their own lusty, cheery fashion -rude and rough, but honest, kindly, and true. Let us thank God if we have outgrown their vices. Let us pray to God that we may ever hold their virtues. The sky may darken, and the clouds may gather, and again the day may come when Britain may have sore need of her children, on whatever shore of the sea they may be found. Shall they not muster at her call?'' As it turned out, Britain did need them again, and they were there - as, in America, they have also been there each time their country has needed them - in war and in peace.
But whence do they come? Are they drawn from among our avaricious merchants, our lying politicians, our thieving lawyers, our self-righteous clerics, our lazy bureaucrats, our self-serving executives, or the numerous other negatively stereotyped groups who make up the American population? Yes, of course, they are. These stereotypes are wrong. We are not a nation of "good'' people and "evil'' people locked endlessly in a struggle with one another. We are, instead, a nation of "ordinary'' people (all of us) responding with the good and evil within each of us to the circumstances in which we find ourselves. Given a glorious opportunity to be for a moment a white knight of the highest order, there is not one American in a thousand who could not rise to that occasion.
We cannot change human nature. We can only hope to adjust the human environment so that it draws out the best qualities within each person and suppresses the worst. Soon, we will be able to read the entire molecular library which contains the genetic code for a whole human being. Will we use this knowledge to eradicate human disease, or will we use it to eradicate human freedom by building a rationale for euthanasia and selective breeding under control of the state? We are, of course, capable of both. Soon, we will have a good understanding of our planet's atmosphere. Will we use this knowledge to enhance our lives through accurate weather prediction and, perhaps someday, benevolent weather manipulation, or will we use it as a rationale for the destruction of human freedom by government control of every human activity that affects the atmosphere?
Each member our civilization (and his descendants for centuries to come) has a critical stake in the answers to these questions and thousands of other similar questions that can be posed concerning advances in science and technology. The answers lie in the guiding ethics that prevail within our communities of scientists and engineers. Our scientists and engineers are, however, just ordinary people. The real question (to restrict ourselves to that which we can hope to affect) is: What are the conditions under which our technologists should live and work which will nurture that within them which is "honest, kindly, and true'' and will help them to "outgrow their vices?'' Well, suppose that we ask them. After all, this is a question about science. We must put ourselves in the hands of (at the mercy of) specialists - at least until the new generation of TV-free home-schooled kids grows old enough to reteach us to think for ourselves.
Today, the almost unanimous answer from academic scientists and the publications of science which they control would be - "Send more government money. The 34 billion tax dollars that we currently receive annually for civilian research and development is not enough. Moreover, it is projected to decrease to about $30 billion by 2002. (See J. Kaiser,
Science 272, p 941(1996).) If you want us to be at our best, you must send more money! Think of it as providing for the common defense - from the chaos that will reign if we are not given a blank check to pursue knowledge.'' But wait, does not the forcible transfer of money from those who earned it to those who did not earn it corrupt the ethics and decrease the productivity of the recipients? From ancient Rome to the modern welfare state, one wretched experiment after another teaches us that people who receive such money sink to very low standards of ethics. Why should you fellows be different?"Oh, but we
are different. We, are scientists. Look at the article by J. Friedly, Science 272, pp 947-948 (1996). In this case, just the suspicion that a government-funded scientist had traced a few lines from a figure in one of his own research papers and republished them in a later paper without revealing the source was the cause of a nine-year investigation by all sorts of ethical bodies including especially the Office of Research Integrity. When we suspected that this scoundrel had plagiarized himself, we spared no expense (of tax dollars) in our decade-long investigation. Science today is as pure as the driven snow, and we intend to keep it that way - if we get enough money.'' The human spirit rises to its highest attainments under a system of free enterprise, and it sinks to its lowest perversities under a system of socialism. Moreover, this latter tendency is one of the most dangerous influences faced by our civilization today - particularly regarding the use of science and technology. Two examples, one past and one ongoing, described in the articles below, may serve to illustrate this.
| Top | Previous | Next |
During the late 1960s and the 1970s, my coworkers and I conceived and built a new procedure for medical diagnosis which had the potential to markedly improve the diagnosis and quantitative evaluation of overt disease and also to make possible the detection of disease long before symptoms were evident, so that preventive medicine could become far more effective. Based upon the fast and inexpensive analysis of large numbers of the ordinary substances produced by human intermediary metabolism, followed by some unique computerized pattern recognition procedures, this approach has the potential to provide a substantial advance in the technological improvement of individual human health. See Access to Energy 23
-4, pp 1-3 for a more complete description. Ultimately, our effort consumed approximately 100 man-years of laboratory work and many millions of dollars in government research grants and private contributions. Overhead from our government-funded profiling grants also provided much of the money that built what later was called the Linus Pauling Institute. In the course of this work, we built the finest entirely automated chromatography equipment that had ever been constructed, carried out tens of thousands of analyses of urine, blood, and breath, and showed that this technique worked for the analysis of conditions ranging from multiple sclerosis and cancer to the degenerative conditions of human aging. This work was done at the University of California at San Diego, Stanford University, and, finally, at the small Institute we founded in Menlo Park, California.One day at Stanford, a young physicist from the Stanford Research Institute (SRI), William Aberth, visited our lab and told me that he had an idea for a new kind of mass spectrometer that would be able to produce a high yield of essentially pure molecular ions (charged but un-fragmented molecules) in a mixture of organic compounds. At that time, there were no mass spectrometers that could do this. He said that he wanted to build this machine and was wondering if I could think of a medical use for it so that money could be obtained.
I suggested that his mass spectrometer be built as a potentially superior technique for the profiling work. Although somewhat inferior in resolution to the chromatographs if built for one mass unit resolution, the resolution could eventually be improved, and this molecular ion mass spectrometer had the potential to be hundreds of times faster than chromatography. This could markedly lower analytical cost, which is a major factor in preventive medicine.
Bill and I therefore agreed upon a collaboration and wrote a government NIH grant request for funds. He would build the mass spectrometer at SRI, and my coworkers and I would provide the computer interface and carry out test experiments using our samples and computational software. Comparison would be made with the diagnostic power of the chromatographic techniques using identical samples. Linus Pauling agreed to put his name on the proposal, too, to help us get the money (your money, if you were paying taxes then). NIGMS (a branch of NIH) liked the idea and fully funded the proposal.
During the following years, at a cost of about $1 million (1996 adj.), William Aberth and his coworkers built an excellent machine, which worked as predicted. Figure 1 shows a human urine mass spec
trum from this device. Figure 2 illustrates one of Bill Aberth's original ideas. Using techniques developed by other scientists at SRI, an array of very tiny volcano-shaped structures was created with a similarly-sized grid registered above them. By introducing the vaporized urine sample through the holes in the volcanoes, each molecule was forced to pass through a controlled electric field high enough to remove one electron from each molecule, but not high enough to fragment the molecule. Once the ions were obtained, they were separated on the basis of their differing charge-to-mass ratios in an ordinary way. Bill and his coworkers at SRI also used a multipoint ionization source with an array of tiny points registered below the grid that worked similarly.
One hitch developed when Bill's work at SRI was transferred to the administrative control of another scientist, Michael Anbar, who inhibited our collaboration in several ways. Anbar, for example, refused to allow us to attach a computer to the mass spectrometer detector, so the output from each sample analysis was a long paper tape containing about 1,000 numbers. These had to be transferred to our computational computer by hand-typed data entry.
In early 1976, the field ion mass spectrometer was submitted to a rigorous test in an experiment requiring 132 analyses of urine from women with breast cancer and appropriate matched controls. Success in this experiment might well have led to a fast and inexpensive test for this disease. Unfortunately, the experiment was unsuccessful. Immediately after that failure, a paper was published in the journal
Clinical Chemistry by Michael Anbar, in which he claimed to have found a disease profile for infectious hepatitis using this mass spectrometer. He failed to report, however, that the ideas and techniques in his paper had been originated by us. Unhappy that we had not been given credit for our ideas and work, Aberth, Pauling, and I published a letter in Clinical Chemistry saying that we actually had invented the technique - although our protestations were weakened by the fact that we did not have successful and publishable results to report.Needing the grant overhead to keep our new Institute running and with the hope that springs eternal in the breast of every welfare-funded research scientist, I continued to seek funding for mass spectrometry work from NIGMS, although I altered the experimental program and was not optimistic about our prospects. To my astonishment, the NIGMS reviewers, led by the grants administrator Robert Melville, generously approved nearly everything I requested even though our experimental results did not warrant this treatment.
Robert Melville was a very fine man. He was dedicated to public service and worked as an administrator at NIH only because he believed that there he could have a valuable impact on human health.
Many years later, after he had retired from government, Melville invited me to dinner at the Cosmos Club in Washington, DC. After dinner, sitting in his parked car on a nighttime Washington street, Bob Melville said that there was something he wanted me to know. He said that he considered it the blackest mark on his career in government. It had to do, he said, with the field ion mass spectrometry work that Bill and I had originated a decade earlier and with our failed experiment.

He told me that, at the time of our breast cancer experiment, he had received at NIGMS a letter from Michael Anbar. In the letter, Anbar admitted that he had secretly scrambled the labels on our 132 samples. Included with the letter was a code sheet Anbar had kept, so that the labels could be unscrambled and the experiment saved. Melville had shown the letter to his superiors, and consideration of its contents had gone to top administrators of the NIH, which oversees most government funded health research. Whereupon, after extensive consideration, Melville had been ordered to tell no one (including us), to destroy the letter and code sheet, and to never speak of the matter again.
It had been concluded that this incident might cause a scandal. It was better for a promising health research experiment to fail and for the scientists involved to not know the reason for their failure than for an NIH-funded project to run the risk of public scandal. (NIH, of course,
did not cause the initial problem. Anbar's letter showed clear signs of a man cracking under the strains of competition. Even so, he had kept an unscrambling code and had voluntarily sent a letter to the grants administrator of the project admitting his actions.) Many of your tax dollars were wasted, and a promising medical research project that might have helped you or someone close to you was damaged - secretly - so that a gaggle of top health research bureaucrats would not have to deal with an uncomfortable situation.Two years later, Bob Melville took one more action - he gave me a copy he had kept of the Anbar letter and the unscrambling code. The date on the letter showed that Anbar's paper in
Clinical Chemistry was being refereed by the journal at the time he scrambled the labels and that it was accepted for publication seven weeks later. He had obviously scrambled the labels to assure that we could not have a positive result before his paper was published. Therefore, he would be able to take credit for ideas and work by Bill and me and our coworkers.Of course, after the strategy had worked and NIH had decided to keep his secret, it was too late to give us the unscrambling code.
Michael Anbar is not, however, the villain of this story. Science will always have individuals who act dishonestly just as does every other profession. Melville's superiors at NIH, who decided to put political expediency above ethics and even above progress on cancer diagnosis, are the villains. Too much power derived from too much money -money seized from other people - breeds this sort of villain.
Yet even now, a decade after I received the code from Melville, I have still not unscrambled the sample labels and calculated the true results of the breast cancer experiment. Why not? Therein lies a second tale that you will not read in the pages of
Science. Although Constance Holden, who is a regular writer on the Science staff, once tried to publish an account in Science about it, the article never appeared. The fact is that, for the past 18 years, I have not been permitted access to any of this data or to my research notes and calculations regarding it.
| Top | Previous | Next |
In 1978, my technicians and I completed a series of experiments on nutrition and cancer in mice that, if appropriately published, might have been embarrassing to Linus Pauling, who then, at the age of 77, was making increasingly wild public claims about Vitamin C and cancer. At the time, I was President of the Linus Pauling Institute of Science and Medicine, and Linus was Chairman of the Board.
In order to prevent publication, Linus convinced his relatives and cronies, who made up a majority of our Board of Directors, to give him control of the Institute. As soon as he obtained control, he locked up all of the Institute's research records, which included over 60 large bound research books, 528 computer data tapes, and about 15 file cabinets filled with printed research records. These records included all of the data from the profiling work that my coworkers and I had done at the University of California at San Diego, Stanford, and the Pauling Institute (which is a 501(c)3 public foundation - with all of its property legally belonging to the public). This publicly-funded health research work comprised about 100 man years of work and cost many millions of tax dollars as well as large amounts of privately donated funds.
Still locked in those records, 18 years later, are over 20 unpublished health research experiments on breast cancer, malignant myeloma, numerous neurological diseases, aging, birth defects, and several other important subjects. Included is the field-ion mass spectrometry data .
Laurelee and I fought a five year legal battle with all of our personal resources to gain access to this data, but we failed. Pauling and his Board simply used huge sums of donated health research funds to give a blank check to lawyers instructed to stop us at any price. Our only success was in forcing Pauling to pay us $575,000 in 1983 for personal damages with $425,000 in payment of libel and slander - but our primary objective, recovery of the research work, was never reached. No one has ever been able to rescue those records from the locked room in which we have been told that they are kept.
At the present time, following Pauling's death, the Linus Pauling Institute is being dissolved, and its assets are being transferred to Ore-gon State University along with permission to use the Institute's name. OSU hopes to be able to raise money using the Pauling name.
During the past year, Dr. Jane Orient and Dr. John Mann have revived a special interest in one of the unpublished experiments. Dr. Mann and his coworkers had provided me with 1,000 urine samples from apparently healthy newborn infants. In the chromatographic profiles of these 1,000 samples, we made a new (still unpublished) discovery in 1978. The profiled substances exhibited bimodal and trimodal distribution functions, making it possible to divide the babies into many distinct groups with respect to their intermediary metabolism. At present, since the babies were born in the Kaiser-Permanente HMO system where Dr. Mann works, his records have subsequent 18-year health histories of these children. Do their health histories correlate with their urine profiles as measured at birth? This is a unique opportunity to answer a question that would otherwise be unanswerable, regardless of resources, for another 18 years. The Pauling Institute has refused to allow Orient and Mann to see the data or my calculations.
So, on June 3, 1996, a federal court in Arizona will consider tens of thousands of dollars of legal motions generated by Pauling Institute lawyers in opposition to Dr. Jane Orient's attempt to see this data . Dr. Orient argues that this data is public property paid for by government grants and tax-deductible donations. Even Oregon State University lawyers are refusing to cooperate with her. The reason - money. What if some of this long-hidden data proves to be of value to human health (and, I assure you, much of it is very valuable)? How much value will the Pauling name have then for their fund-raising program?
Is Linus Pauling the villain here? Not entirely. The fact that he seized the research records of numerous scientists, thereby preventing continuation or publication of their work is well known to many scientists. They are afraid, however, that scandal involving a big-name scientist will affect government funding. Everyone keeps quiet. Anyone risking the $34 billion piggy bank risks the displeasure of his peers.
| Top | Previous | Next |
This year's DDP meeting will be held on August 2-4 at the Airport Hilton in Salt Lake City. It will feature an extraordinarily outstanding group of speakers. Their names and subjects include:
Glen Griffin, pediatrician -School-based Clinics. Jim Phillips and Gary Barnes - Personal Survival. Gordon Edwards - DDT, Alligators, and Regulatory Atrocities. Sallie Baliunas, astrophysicist, - Global Climate Stanford Penner, aerospace physicist - Environment Management Robert Jastrow, astronomer - Missile Defense Gary Sandquist, nuclear engineer - Beneficial Low-level Radiation S. Fred Singer - Stratospheric Ozone and Political Correctness Martin Kamen, discoverer of C Stanley Monteith, orthopedic surgeon - AIDS and Public Health Henry I. Miller - Anti-Medicine: The FDA and Medical Progress Cresson Kearny - Land Mines and other Government Snafus Edwin York - Soviet Shelters for Industrial Workers Christopher Story - Soviet-Chinese Strategic Deception Sam Cohen - U. S. Defense Policy and Technological Risks Sharon Packer and Paul Seyfried - Shelter Construction Conrad Chester - Surviving Biological Contamination
These speakers include some of the most outstanding scientists and experts in the world speaking about subjects that are of immediate importance to the well-being of most Americans. The DDP speakers and meeting are organized each year by Dr. Jane Orient. These programs are unequaled for the stature of the lecturers and the relevance of their topics. If you can attend even one conference in 1996, this should definitely be the one. I look forward to seeing in August the many Access to Energy readers who regularly attend these meetings.
Information and reservations are available from DDP, 2509 N. Campbell, Box 272, Tucson, AZ 85719. Telephone (520) 325-2680. Registration cost for the meeting, including two lunches and the banquet, is $95. Airport Hilton rooms are $79 per night, single or double.
| Top | Previous | Next |
Are Human Activities Causing Global Warming?
recently published by the George Marshall Institute, 1730 M Street, N.W., Suite 502, Washington, DC 20036, is an excellent update and summary of the principal facts in opposition to the global warming mania.Some of the primary points are:
1. Contrary to media hype, 1995 was not the "hottest year on record.'' Satellite measurements rank it as eighth in the last 17 years.
2. Updated satellite records now show a warming of 0.09 ºC per decade since 1980. This rate is well within the naturally fluctuating temperature changes observed in the years before the release of significant amounts of greenhouse gases by human activity.
3. Most of the 1 ºC temperature rise during the past 100 years occurred before 1940 and therefore before the release of significant amounts of greenhouse gases from human activity.
4. The historical record, contrary to enviro propaganda, shows that warmer periods are associated with
less extreme weather conditions and do not give rise to more hurricanes, tornadoes, floods, and blizzards. In fact, in the 10th to 12th centuries, the temperature was about 0.5 ºC warmer than it is today, and the climate was so benign that this period is known as the Medieval Climatic Optimum. This is the temperature that climate models are predicting for the years 2030 to 2050.5. Arctic temperatures have actually
decreased for the last 40 years.6. There is, as yet, no trace of global warming due to human activity, so any such future warming is expected to be less than 1 ºC.
Robert Jastrow, President of the Marshall Institute, and Sallie Bali-unas, Chairman of the Marshall Institute Science Advisory Board, will both be speaking at the DDP meeting in Salt Lake City.
| Top | Previous | Next |
If President Bush's "thousand points of light'' speech were coupled with a demand for government-funded wind generators to power the points of light and then rewritten by New Age poets, it still would be outclassed by Gore's offering. We believe (reluctantly) that Gore said it. It is difficult to believe that
Science published it.
| Top | Previous | Next |
NOTE: The May 1996
Access to Energy editorial should read: "temperature increase preceded the CO2 increase,'' not vice versa.